产品货号：
Z15492
中文名称：
EBI3抗体
英文名称：
Anti-EBI3 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-EBI3 Antibody |
| 指标别名 | EBI3;EBV induced gene 3 protein;Epstein Barr virus induced 3;IL 27 subunit beta;IL 27B;IL27B;Interleukin 27 subunit beta |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | EBI3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-EBI-3 antibody was raised against a peptide corresponding to 16 amino acids near the center of mature human EBI-3.The immunogen is located within amino acids 150 - 200 of EBI3. |
| 计算分子量 | 25kDa |
| 成分 | EBI3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | EBI3 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | EBI3 is a subunit in two distinct heterodimeric cytokines:interleukin-27 (IL-27) and IL-35.Like interleukin-23 (IL-23),IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines.It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28.IL-27 is produced after activation by antigen-presenting cells and induces proliferation of na?ve but not memory CD4+ T-cells.It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade,suggesting the IL-27 is involved in the regulation of immune processes.It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells,IFN-gamma,and T-bet.IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells.At least two isoform of EBI3 are known to exist. |
| Uniprot ID | Q14213 |
| 基因名全称 | Epstein-Barr virus induced 3 |
| 蛋白名全称 | Epstein-Barr virus induced 3 |
| 推荐稀释比 | WB:0.5 ～ 2μg/mL;IF:20μg/mL;IHC:2.5μg/mL;.Antibody validated:Western Blot in human and rat samples;Immunofluorescence and Immunohistochemistry in human samples.All other applications and species not yet tested. |
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